Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1C4 | P17516 | 1/20 | 0.45 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.45 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.45 |
| ▸ | LDHA | P00338 | 2/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.41 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | FABP4 | P15090 | 5/20 | 0.36 |
| ▸ | FABP5 | Q01469 | 5/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CCR5 | P51681 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30639580 | 0.85 | CYP1A2 (0.42) | AKR1C4AKR1C3AKR1C2AKR1C1LDHA | |
| SCHEMBL13853476 | 0.84 | HSD11B1 (0.41) | AKR1C4AKR1C3AKR1C2AKR1C1LDHA | |
| SCHEMBL3954081 | 0.80 | HTT (0.48) | HSD11B1MEN1KMT2AGAA | |
| SCHEMBL13731980 | 0.76 | CYP2C9 (0.39) | KMT2ACYP1A2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL30639536 | 0.75 | HSD11B1 (0.42) | AKR1C4AKR1C3AKR1C2AKR1C1LDHA | |
| Hydrochloric Acid SCHEMBL30639619 | 0.74 | HSD11B1 (0.41) | AKR1C4AKR1C3AKR1C2AKR1C1LDHA | |
| SCHEMBL4224253 | 0.72 | KDM4E (0.38) | L3MBTL1KMT2ACYP1A2CYP2D6CYP2C9 | |
| SCHEMBL26226450 | 0.72 | L3MBTL1 (0.44) | AKR1C4AKR1C3AKR1C2AKR1C1LDHA | |
| SCHEMBL1786515 | 0.72 | L3MBTL1 (0.44) | AKR1C4AKR1C3AKR1C2AKR1C1LDHA | |
| SCHEMBL24258804 | 0.72 | AKR1C4 (0.44) | AKR1C4AKR1C3AKR1C2AKR1C1LDHA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8354418-B2 | Thiazolyl-dihydro-quinazolines | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2013-01-15 | — | — | US | disclosed |
| US-20090131424-A1 | THIAZOLYL-DIHYDRO-CHINAZOLINE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2009-05-21 | — | — | US | disclosed |
| US-20070259855-A1 | THIAZOLYL-DIHYDRO-INDAZOLE | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2007-11-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070259855-A1 | THIAZOLYL-DIHYDRO-INDAZOLE | ROR1, RORB, RORA | AKR1C4 120/4885AKR1C3 163/4885AKR1C2 186/4885 |
| US-20090131424-A1 | THIAZOLYL-DIHYDRO-CHINAZOLINE | CYP3A7, UGT2B7, UGT1A7 | AKR1C4 484/4885AKR1C3 706/4885AKR1C2 762/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.