Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | ADH1B | P00325 | 3/20 | 0.41 |
| ▸ | ADH1A | P07327 | 3/20 | 0.41 |
| ▸ | ADH1C | P00326 | 2/20 | 0.41 |
| ▸ | ADH7 | P40394 | 2/20 | 0.38 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | CASP1 | P29466 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12418621 | 0.88 | ALDH1A1 (0.39) | HPGDALDH1A1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL14215543 | 0.86 | SMN1; SMN2 (0.49) | HPGDALDH1A1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL18908668 | 0.85 | SMN1; SMN2 (0.59) | HPGDALDH1A1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL22215134 | 0.83 | ADH1B (0.39) | HPGDALDH1A1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL23918721 | 0.83 | SMN1; SMN2 (0.51) | HPGDALDH1A1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL12410354 | 0.81 | USP2 (0.36) | HPGDALDH1A1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL18199495 | 0.81 | SMN1; SMN2 (0.66) | HPGDALDH1A1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL25100443 | 0.77 | SMN1; SMN2 (0.43) | HPGDALDH1A1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL23665086 | 0.77 | KMT2A (0.56) | HPGDALDH1A1KMT2ASMN1; SMN2TP53 | |
| SCHEMBL14896643 | 0.77 | MEN1 (0.62) | KMT2AADH1BADH1AADH1CADH7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3432934-B1 | PRODRUGS OF CYTOTOXIC AGENTS WITH ENZYMATICALLY CLEAVABLE GROUPS | Bayer Pharma AG (DE) | 2022-02-23 | — | — | EP | disclosed |