Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP26B1 | Q9NR63 | 5/20 | 0.57 |
| ▸ | CYP26A1 | O43174 | 7/20 | 0.45 |
| ▸ | NAMPT | P43490 | 2/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.40 |
| ▸ | RXRA | P19793 | 2/20 | 0.39 |
| ▸ | RXRB | P28702 | 2/20 | 0.39 |
| ▸ | RXRG | P48443 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.38 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.38 |
| ▸ | SPPL2A | Q8TCT8 | 1/20 | 0.38 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.38 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.38 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.38 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.38 |
| ▸ | RARA | P10276 | 1/20 | 0.38 |
| ▸ | RARB | P10826 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17911591 | 0.84 | CYP26B1 (0.66) | CYP26B1CYP26A1RXRARXRBRXRG | |
| SCHEMBL12051265 | 0.81 | LOXL2 (0.55) | NAMPTLOXL2HTR6ALDH1A1TSHR | |
| SCHEMBL16516901 | 0.81 | CYP26B1 (0.56) | CYP26B1CYP26A1NAMPTRXRARXRB | |
| SCHEMBL10180577 | 0.76 | HTR6 (0.64) | NAMPTLOXL2HTR6ALDH1A1TSHR | |
| SCHEMBL16516315 | 0.76 | CYP26B1 (0.50) | CYP26B1CYP26A1RXRARXRBRXRG | |
| SCHEMBL3176733 | 0.76 | RXRA (0.54) | CYP26B1CYP26A1RXRARXRBRXRG | |
| SCHEMBL16516911 | 0.75 | CYP26B1 (0.77) | CYP26B1CYP26A1RXRARXRBRXRG | |
| SCHEMBL30175054 | 0.75 | CYP26B1 (0.60) | CYP26B1CYP26A1RXRARXRBRXRG | |
| SCHEMBL8013234 | 0.75 | CYP26B1 (0.58) | CYP26B1CYP26A1RXRARXRBRXRG | |
| SCHEMBL23897669 | 0.73 | KMT2A (0.50) | NAMPTLOXL2HTR6ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3044216-B1 | NOVEL AND SPECIFIC INHIBITORS OF CYTOCHROME P450 26 RETINOIC ACID HYDROXYLASE | UNIV WASHINGTON THROUGH ITS CENTER FOR COMMERCIALIZATION (US) | 2022-02-23 | — | — | EP | disclosed |