Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 8/20 | 0.68 |
| ▸ | SORT1 | Q99523 | 8/20 | 0.68 |
| ▸ | CACNA1I | Q9P0X4 | 9/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.46 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24283555 | 0.93 | GRN (0.70) | GRNSORT1CACNA1IKCNH2GPR139 | |
| SCHEMBL24283494 | 0.81 | GRN (1.00) | GRNSORT1CACNA1I | |
| SCHEMBL1829148 | 0.75 | GRN (0.60) | GRNSORT1GPR139HPGD | |
| SCHEMBL24283553 | 0.74 | GRN (1.00) | GRNSORT1 | |
| SCHEMBL7865822 | 0.72 | GRN (0.57) | GRNSORT1CACNA1IKCNH2GPR139 | |
| SCHEMBL13754437 | 0.72 | GRN (0.50) | GRNSORT1GPR139HPGD | |
| SCHEMBL24283477 | 0.72 | NPC1 (0.63) | GRNSORT1GPR139HPGD | |
| SCHEMBL1123422 | 0.71 | CTSL (0.48) | GRNSORT1HPGD | |
| SCHEMBL23213655 | 0.70 | GRN (0.64) | GRNSORT1GPR139 | |
| SCHEMBL23213654 | 0.70 | GRN (0.64) | GRNSORT1GPR139 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3981394-A1 | A SORTILIN ANTAGONIST FOR USE IN THE PREVENTION OR TREATMENT OF HEARING LOSS. | Insusense ApS (DK) | 2022-04-13 | — | — | EP | disclosed |