Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRN | P28799 | 8/20 | 0.70 |
| ▸ | SORT1 | Q99523 | 8/20 | 0.70 |
| ▸ | CCKBR | P32239 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 2/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.44 |
| ▸ | CACNA1I | Q9P0X4 | 4/20 | 0.44 |
| ▸ | GPR139 | Q6DWJ6 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSS | P25774 | 1/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | TAS1R2 | Q8TE23 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24283495 | 0.93 | GRN (0.68) | GRNSORT1KCNH2CACNA1IGPR139 | |
| SCHEMBL24283553 | 0.82 | GRN (1.00) | GRNSORT1CCKBRCTSKCTSL | |
| SCHEMBL1123422 | 0.79 | CTSL (0.48) | GRNSORT1CTSKHPGDCTSL | |
| SCHEMBL1829148 | 0.75 | GRN (0.60) | GRNSORT1GPR139HPGD | |
| SCHEMBL24283494 | 0.74 | GRN (1.00) | GRNSORT1CCKBRCACNA1ICTSL | |
| SCHEMBL26541515 | 0.73 | TAS1R3 (0.53) | GRNSORT1CACNA1IGPR139TAS1R3 | |
| SCHEMBL13761539 | 0.73 | RAB9A (0.64) | CTSKHPGDCTSLCTSBCTSS | |
| SCHEMBL13754271 | 0.73 | RAB9A (0.64) | CTSKHPGDCTSLCTSBCTSS | |
| SCHEMBL6478192 | 0.72 | METAP2 (0.80) | GRNSORT1METAP2 | |
| SCHEMBL12506241 | 0.72 | CTSK (0.55) | CTSKHPGDCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3981394-A1 | A SORTILIN ANTAGONIST FOR USE IN THE PREVENTION OR TREATMENT OF HEARING LOSS. | Insusense ApS (DK) | 2022-04-13 | — | — | EP | disclosed |