Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.45 |
| ▸ | KCNH3 | Q9ULD8 | 2/20 | 0.39 |
| ▸ | BCL6 | P41182 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.36 |
| ▸ | IDH1 | O75874 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.35 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | GPR6 | P46095 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24288096 | 0.84 | RPS6KA3 (0.44) | RPS6KA3MAPK14MAPK8ABL1HDAC6 | |
| SCHEMBL24288255 | 0.81 | USP2 (0.42) | MAPK14MAPK8BCL6ALOX5APFEN1 | |
| SCHEMBL24288140 | 0.77 | KMO (0.38) | MAPK14ALOX5APFEN1 | |
| SCHEMBL1516811 | 0.75 | MAPK14 (0.48) | MAPK14MAPK8BCL6PSEN1PSEN2 | |
| SCHEMBL27095191 | 0.75 | KMO (0.36) | ABL1ALOX5APFEN1 | |
| SCHEMBL27095285 | 0.74 | MAPK8 (0.40) | RPS6KA3MAPK14MAPK8PSEN1PSEN2 | |
| SCHEMBL24288091 | 0.74 | MAP4K4 (0.40) | MAPK14MAPK8ABL1 | |
| SCHEMBL1517280 | 0.74 | RPS6KA3 (0.44) | RPS6KA3MAPK14MAPK8KCNH3BCL6 | |
| SCHEMBL1517063 | 0.73 | MAPK14 (0.42) | RPS6KA3MAPK14MAPK8KCNH3BCL6 | |
| SCHEMBL1516990 | 0.73 | RPS6KA3 (0.46) | RPS6KA3MAPK14MAPK8KCNH3ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022053823-A1 | SUBSTITUTED PYRIMIDINE DERIVATIVES AS NICOTINIC ACETYLCHOLINESTERASE RECEPTOR ALPHA 6 MODULATOR | Cerevance, Inc. (US) | 2022-03-17 | — | — | WO | disclosed |