Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | RAB9A | P51151 | 5/20 | 0.35 |
| ▸ | NPC1 | O15118 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD4 | P21917 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 3/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17757029 | 0.78 | MEN1 (0.41) | MEN1KMT2ARAB9ANPC1LMNA | |
| SCHEMBL17757905 | 0.68 | MEN1 (0.42) | MEN1KMT2ARAB9ANPC1LMNA | |
| SCHEMBL17757743 | 0.68 | MEN1 (0.41) | MEN1KMT2ARAB9ANPC1LMNA | |
| SCHEMBL17757549 | 0.67 | MEN1 (0.41) | MEN1KMT2ARAB9ANPC1LMNA | |
| SCHEMBL17757053 | 0.63 | DRD2 (0.41) | MEN1KMT2ALMNAHTR1ADRD2 | |
| SCHEMBL17757034 | 0.62 | GPR84 (0.36) | MEN1KMT2ARAB9ANPC1MAPT | |
| SCHEMBL1379940 | 0.60 | RAB9A (0.44) | MEN1KMT2ARAB9ANPC1PKM | |
| SCHEMBL17757035 | 0.60 | ACAT2 (0.34) | MEN1KMT2ARAB9ANPC1HTR1A | |
| SCHEMBL17757325 | 0.59 | PIK3CA (0.39) | MEN1KMT2ARAB9ANPC1LMNA | |
| SCHEMBL1380879 | 0.58 | MEN1 (0.43) | MEN1KMT2ARAB9ANPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE48992-E1 | Spiroquinoxaline derivatives as inhibitors of non-apoptotic regulated cell-death | HELMHOLTZ ZENTRUM MÜNCHEN-DEUTSCHES FORSCHUNGSZENTRUM FÜR GESUNDHEIT UND UMWELT (GMBH) (DE) | 2022-03-29 | — | — | US | disclosed |