Sugi Predict

Sugi Predict / Compounds / SCHEMBL24300050

SCHEMBL24300050

SCHEMBL24300050

COC(=O)[C@H](COC[C@H]1CCCN1C(=O)OC(C)(C)C)NC(=O)OCc1ccccc1

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CTSK P43235 7/20 0.46
▸ CTSL P07711 6/20 0.46
▸ CTSS P25774 4/20 0.46
▸ ACE P12821 2/20 0.46
▸ PREP P48147 2/20 0.46
▸ ATM Q13315 1/20 0.45
▸ L3MBTL1 Q9Y468 1/20 0.45
▸ YAP1 P46937 1/20 0.45
▸ ADORA3 P0DMS8 1/20 0.44
▸ ADORA2A P29274 1/20 0.44
▸ ADORA2B P29275 1/20 0.44
▸ ADORA1 P30542 1/20 0.44
▸ KLK7 P49862 1/20 0.44
▸ KLK5 Q9Y337 1/20 0.44
▸ SYK P43405 1/20 0.44
▸ PPARA Q07869 1/20 0.44
▸ CTSB P07858 2/20 0.44
▸ ALDH1A1 P00352 1/20 0.44
▸ CYP3A4 P08684 1/20 0.44
▸ TSHR P16473 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29253451 1.00 CTSK (0.46) CTSKCTSLCTSSACEPREP
SCHEMBL19255758 1.00 CTSK (0.46) CTSKCTSLCTSSACEPREP
SCHEMBL28456201 0.97 ATM (0.49) CTSKCTSLCTSSACEPREP
SCHEMBL28456203 0.97 ATM (0.49) CTSKCTSLCTSSACEPREP
SCHEMBL29253240 0.97 ATM (0.49) CTSKCTSLCTSSACEPREP
SCHEMBL22370631 0.94 PPARA (0.52) CTSKCTSLCTSSACEPREP
SCHEMBL22370634 0.94 PPARA (0.52) CTSKCTSLCTSSACEPREP
SCHEMBL20556491 0.89 ACE (0.49) CTSKCTSLCTSSACEPREP
SCHEMBL20556489 0.89 ACE (0.49) CTSKCTSLCTSSACEPREP
SCHEMBL20556490 0.89 ACE (0.49) CTSKCTSLCTSSACEPREP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3710458-B1 IMMUNOPROTEASOME INHIBITORS PRINCIPIA BIOPHARMA INC (US) 2026-03-25 — — EP disclosed
US-12312370-B2 Immunoproteasome inhibitors PRINCIPIA BIOPHARMA INC. (US) 2025-05-27 — — US disclosed
US-20240199655-A1 Immunoproteasome Inhibitors PRINCIPIA BIOPHARMA INC. (US) 2024-06-20 — — US disclosed
CN-111491938-B Immunoproteasome inhibitors 普林斯匹亚生物制药公司 2024-05-24 — — CN disclosed
US-11827656-B2 Immunoproteasome inhibitors PRINCIPIA BIOPHARMA INC. (US) 2023-11-28 — — US disclosed
US-11827656-B2 Immunoproteasome inhibitors PRINCIPIA BIOPHARMA INC. (US) 2023-11-28 — — US disclosed
US-11827656-B2 Immunoproteasome inhibitors PRINCIPIA BIOPHARMA INC. (US) 2023-11-28 — — US disclosed
US-20220073538-A1 Immunoproteasome Inhibitors PRINCIPIA BIOPHARMA INC. (US) 2022-03-10 — — US disclosed
US-20220073538-A1 Immunoproteasome Inhibitors PRINCIPIA BIOPHARMA INC. (US) 2022-03-10 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11827656-B2 Immunoproteasome inhibitors PSMC2, PSMB7, PSMB2 CTSK 227/4885CTSL 534/4885CTSS 133/4885
US-20240199655-A1 Immunoproteasome Inhibitors PSMC2, PSMB7, PSMB2 CTSK 227/4885CTSL 534/4885CTSS 133/4885
US-12312370-B2 Immunoproteasome inhibitors PSMC2, PSMB7, PSMB2 CTSK 227/4885CTSL 534/4885CTSS 133/4885
US-20220073538-A1 Immunoproteasome Inhibitors PSMC2, PSMB7, PSMB2 CTSK 227/4885CTSL 534/4885CTSS 133/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.