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Sugi Predict / Compounds / SCHEMBL28456201

SCHEMBL28456201

SCHEMBL28456201

COC(=O)[C@H](COC[C@H]1CCCCN1C(=O)OC(C)(C)C)NC(=O)OCc1ccccc1

nearest known ligand 0.49

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ ATM Q13315 1/20 0.49
▸ L3MBTL1 Q9Y468 1/20 0.49
▸ FKBP1A P62942 1/20 0.45
▸ YAP1 P46937 1/20 0.44
▸ KDM1A O60341 1/20 0.44
▸ CTSK P43235 6/20 0.44
▸ CTSL P07711 6/20 0.44
▸ CTSS P25774 3/20 0.44
▸ KLK7 P49862 1/20 0.44
▸ KLK5 Q9Y337 1/20 0.44
▸ SYK P43405 1/20 0.43
▸ PPARA Q07869 1/20 0.43
▸ ACE P12821 1/20 0.43
▸ ABHD6 Q9BV23 1/20 0.43
▸ DAGLA Q9Y4D2 1/20 0.43
▸ PREP P48147 2/20 0.43
▸ PRMT5 O14744 1/20 0.43
▸ CTSB P07858 2/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28456203 1.00 ATM (0.49) ATML3MBTL1FKBP1AYAP1KDM1A
SCHEMBL29253240 1.00 ATM (0.49) ATML3MBTL1FKBP1AYAP1KDM1A
SCHEMBL24300050 0.97 CTSK (0.46) ATML3MBTL1YAP1CTSKCTSL
SCHEMBL19255758 0.97 CTSK (0.46) ATML3MBTL1YAP1CTSKCTSL
SCHEMBL29253451 0.97 CTSK (0.46) ATML3MBTL1YAP1CTSKCTSL
SCHEMBL22370631 0.91 PPARA (0.52) YAP1CTSKCTSLCTSSKLK7
SCHEMBL22370634 0.91 PPARA (0.52) YAP1CTSKCTSLCTSSKLK7
SCHEMBL22370727 0.89 ATM (0.53) ATML3MBTL1FKBP1ACTSKCTSL
SCHEMBL22370724 0.89 ATM (0.53) ATML3MBTL1FKBP1ACTSKCTSL
SCHEMBL22370720 0.89 ATM (0.53) ATML3MBTL1FKBP1ACTSKCTSL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3710458-B1 IMMUNOPROTEASOME INHIBITORS PRINCIPIA BIOPHARMA INC (US) 2026-03-25 — — EP disclosed
US-12312370-B2 Immunoproteasome inhibitors PRINCIPIA BIOPHARMA INC. (US) 2025-05-27 — — US disclosed
US-20240199655-A1 Immunoproteasome Inhibitors PRINCIPIA BIOPHARMA INC. (US) 2024-06-20 — — US disclosed
US-11827656-B2 Immunoproteasome inhibitors PRINCIPIA BIOPHARMA INC. (US) 2023-11-28 — — US disclosed
US-20220073538-A1 Immunoproteasome Inhibitors PRINCIPIA BIOPHARMA INC. (US) 2022-03-10 — — US disclosed
CN-111491938-A Immunoproteasome inhibitors 普林斯匹亚生物制药公司 2020-08-04 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11827656-B2 Immunoproteasome inhibitors PSMC2, PSMB7, PSMB2 ATM 3544/4885L3MBTL1 3263/4885FKBP1A 594/4885
US-20240199655-A1 Immunoproteasome Inhibitors PSMC2, PSMB7, PSMB2 ATM 3544/4885L3MBTL1 3263/4885FKBP1A 594/4885
US-12312370-B2 Immunoproteasome inhibitors PSMC2, PSMB7, PSMB2 ATM 3544/4885L3MBTL1 3263/4885FKBP1A 594/4885
US-20220073538-A1 Immunoproteasome Inhibitors PSMC2, PSMB7, PSMB2 ATM 3544/4885L3MBTL1 3263/4885FKBP1A 594/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.