Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.35 |
| ▸ | WNT1 | P04628 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | TTK | P33981 | 1/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 7/20 | 0.35 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.32 |
| ▸ | PIM1 | P11309 | 1/20 | 0.32 |
| ▸ | FLT3 | P36888 | 2/20 | 0.31 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.31 |
| ▸ | CLK2 | P49760 | 1/20 | 0.31 |
| ▸ | CLK3 | P49761 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309238 | 0.85 | MAP4K1 (0.36) | TTKMAP4K1TNK2EGLN1HRH4 | |
| SCHEMBL24309686 | 0.84 | EGFR (0.37) | DYRK1AWNT1GSK3BTTKMAP4K1 | |
| SCHEMBL29566817 | 0.84 | EGFR (0.37) | DYRK1AWNT1GSK3BTTKMAP4K1 | |
| SCHEMBL24310284 | 0.82 | MAP4K1 (0.37) | MAP4K1TNK2HRH4 | |
| SCHEMBL24310751 | 0.82 | MAP4K1 (0.34) | MAP4K1TNK2PTK2 | |
| SCHEMBL24309422 | 0.81 | MAP4K1 (0.33) | GSK3BMAP4K1TNK2PIM1 | |
| SCHEMBL24309518 | 0.81 | LMNA (0.39) | MAP4K1 | |
| SCHEMBL24309575 | 0.81 | NPC1 (0.33) | — | |
| SCHEMBL24310753 | 0.81 | MAP4K1 (0.37) | MAP4K1TNK2PTK2 | |
| SCHEMBL24309556 | 0.79 | MAP4K1 (0.35) | MAP4K1PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |