Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 3/20 | 0.37 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | EGFR | P00533 | 3/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 4/20 | 0.33 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.33 |
| ▸ | CCNK | O75909 | 2/20 | 0.32 |
| ▸ | CCND3 | P30281 | 2/20 | 0.32 |
| ▸ | CDK9 | P50750 | 2/20 | 0.32 |
| ▸ | CDK6 | Q00534 | 2/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | LCK | P06239 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310751 | 0.87 | MAP4K1 (0.34) | MAP4K1IRAK4EGFRTNK2IGF1R | |
| SCHEMBL24309442 | 0.84 | BRD4 (0.37) | MAP4K1IRAK4EGFRTNK2BRD4 | |
| SCHEMBL29566947 | 0.84 | BRD4 (0.37) | MAP4K1IRAK4EGFRTNK2BRD4 | |
| SCHEMBL24309954 | 0.83 | HTR1D (0.36) | MAP4K1EGFR | |
| SCHEMBL24310533 | 0.83 | MAP4K1 (0.35) | MAP4K1EGFR | |
| SCHEMBL24310284 | 0.81 | MAP4K1 (0.37) | MAP4K1TNK2BRD4 | |
| SCHEMBL24309575 | 0.81 | NPC1 (0.33) | BRD4 | |
| SCHEMBL24309583 | 0.81 | DYRK1A (0.35) | MAP4K1TNK2PTK2 | |
| SCHEMBL24309422 | 0.81 | MAP4K1 (0.33) | MAP4K1TNK2BRD4CCNKCCND3 | |
| SCHEMBL24309553 | 0.79 | MAP4K1 (0.31) | MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |