Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.33 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.32 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.32 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.32 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.32 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.32 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.31 |
| ▸ | CDK2 | P24941 | 5/20 | 0.31 |
| ▸ | CCNA1 | P78396 | 5/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CDK4 | P11802 | 3/20 | 0.31 |
| ▸ | CCND3 | P30281 | 3/20 | 0.31 |
| ▸ | GSK3B | P49841 | 3/20 | 0.31 |
| ▸ | PIM1 | P11309 | 2/20 | 0.31 |
| ▸ | AURKA | O14965 | 1/20 | 0.30 |
| ▸ | CCNK | O75909 | 1/20 | 0.30 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.30 |
| ▸ | MTOR | P42345 | 1/20 | 0.30 |
| ▸ | CDK12 | Q9NYV4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310751 | 0.88 | MAP4K1 (0.34) | MAP4K1TNK2SLC2A1 | |
| SCHEMBL24309872 | 0.85 | CCNA2 (0.40) | CCNA2CDK2CCNA1BRD4CDK4 | |
| SCHEMBL24310427 | 0.84 | PLK1 (0.33) | MAP4K1CCNA2CDK2CCNA1 | |
| SCHEMBL29566394 | 0.84 | BRD4 (0.36) | MAP4K1FGFR1FGFR2FGFR3TNK2 | |
| SCHEMBL24309421 | 0.84 | BRD4 (0.36) | MAP4K1FGFR1FGFR2FGFR3TNK2 | |
| SCHEMBL24309575 | 0.82 | NPC1 (0.33) | BRD4MTOR | |
| SCHEMBL24309583 | 0.81 | DYRK1A (0.35) | MAP4K1TNK2GSK3BPIM1 | |
| SCHEMBL24309954 | 0.81 | HTR1D (0.36) | MAP4K1SLC2A1 | |
| SCHEMBL24309518 | 0.81 | LMNA (0.39) | MAP4K1BRD4 | |
| SCHEMBL24310284 | 0.81 | MAP4K1 (0.37) | MAP4K1TNK2BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |