Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.35 |
| ▸ | NAMPT | P43490 | 2/20 | 0.34 |
| ▸ | GCG | P01275 | 4/20 | 0.34 |
| ▸ | GCGR | P47871 | 3/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 2/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGAV | P06756 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310126 | 0.86 | AURKA (0.36) | AURKAAURKBLMNA | |
| SCHEMBL24310100 | 0.86 | USP2 (0.39) | BCHECNR2PRMT5NAMPTNPC1 | |
| SCHEMBL24309567 | 0.82 | PTK2 (0.39) | LMNA | |
| SCHEMBL24310347 | 0.81 | GPR39 (0.39) | NPC1RAB9AAURKAAURKBLMNA | |
| SCHEMBL24310563 | 0.81 | HPGD (0.31) | — | |
| SCHEMBL24310796 | 0.80 | F10 (0.43) | — | |
| SCHEMBL24310788 | 0.80 | P2RX7 (0.34) | AURKAAURKB | |
| SCHEMBL24310557 | 0.80 | DGAT2 (0.32) | — | |
| SCHEMBL24310142 | 0.79 | GPR39 (0.30) | — | |
| SCHEMBL24309553 | 0.78 | MAP4K1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |