Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | PCTP | Q9UKL6 | 1/20 | 0.38 |
| ▸ | STARD10 | Q9Y365 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | FNTA | P49354 | 1/20 | 0.36 |
| ▸ | FNTB | P49356 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310519 | 0.85 | TSHR (0.40) | TSHRPKMLMNAPCTPSTARD10 | |
| SCHEMBL26807044 | 0.81 | LMNA (0.56) | LMNAALDH1A1KMT2AMEN1MAPT | |
| SCHEMBL24310735 | 0.79 | PIK3CD (0.39) | TSHRPKMGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL26833740 | 0.74 | KMT2A (0.47) | TSHRLMNAHPGDSMN1; SMN2ALDH1A1 | |
| SCHEMBL29566636 | 0.73 | GAA (0.35) | TSHRLMNAGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL26651236 | 0.73 | GAA (0.35) | TSHRLMNAGAASMN1; SMN2ALDH1A1 | |
| SCHEMBL26822143 | 0.72 | CYTH2 (0.45) | TSHRPKMPCTPSTARD10GAA | |
| SCHEMBL24309265 | 0.71 | MAPT (0.63) | TSHRPKMLMNAGAAHPGD | |
| SCHEMBL26849718 | 0.71 | HTR6 (0.44) | TSHRPKMLMNAGAASMN1; SMN2 | |
| SCHEMBL29567025 | 0.71 | LMNA (0.54) | LMNAALDH1A1KMT2AMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |