Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | CCR4 | P51679 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26651236 | 1.00 | GAA (0.35) | GAALMNAALDH1A1RXFP1L3MBTL1 | |
| SCHEMBL24309340 | 0.81 | USP1 (0.31) | GAALMNAALDH1A1CCR4TSHR | |
| SCHEMBL29567059 | 0.81 | USP1 (0.31) | GAALMNAALDH1A1CCR4TSHR | |
| SCHEMBL24310735 | 0.80 | PIK3CD (0.39) | GAAALDH1A1POLBTSHRKMT2A | |
| SCHEMBL24310518 | 0.73 | TSHR (0.40) | GAALMNAALDH1A1TSHRKMT2A | |
| SCHEMBL26807044 | 0.71 | LMNA (0.56) | LMNAALDH1A1L3MBTL1KMT2AMEN1 | |
| SCHEMBL24309239 | 0.69 | CCNT1 (0.40) | GAAALDH1A1POLBTSHRKMT2A | |
| SCHEMBL26806587 | 0.69 | TSHR (0.40) | GAAALDH1A1POLBHTTTSHR | |
| SCHEMBL29566540 | 0.68 | BRD4 (0.37) | GAALMNACCR4POLBHTT | |
| SCHEMBL24309952 | 0.68 | MAP4K1 (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4225748-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | Vertex Pharmaceuticals Incorporated (US) | 2023-08-16 | — | — | EP | disclosed |
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |