Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 6/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | DGAT2 | Q96PD7 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 3/20 | 0.37 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.35 |
| ▸ | SELE | P16581 | 1/20 | 0.35 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | CTSC | P53634 | 1/20 | 0.35 |
| ▸ | CCNC | P24863 | 1/20 | 0.35 |
| ▸ | CDK8 | P49336 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309743 | 0.91 | LTA4H (0.41) | BRD4 | |
| SCHEMBL24310318 | 0.85 | MAP4K1 (0.42) | — | |
| SCHEMBL24309787 | 0.85 | MAPT (0.36) | — | |
| SCHEMBL24309803 | 0.81 | DRD3 (0.37) | EGFRIRAK4PTK2 | |
| SCHEMBL29566336 | 0.81 | DGAT2 (0.42) | BRD4METDGAT2EGFRFGFR4 | |
| SCHEMBL24309631 | 0.81 | DGAT2 (0.42) | BRD4METDGAT2EGFRFGFR4 | |
| SCHEMBL24310306 | 0.79 | CDK4 (0.34) | BRD4METEGFR | |
| SCHEMBL24309690 | 0.77 | HRH3 (0.39) | TTKCCNCCDK8 | |
| SCHEMBL24309866 | 0.77 | FLT3 (0.36) | BRD4 | |
| SCHEMBL24310424 | 0.76 | PDE2A (0.41) | EGFRTTKCTSC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |