Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 4/20 | 0.41 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.36 |
| ▸ | HTR3A | P46098 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | NMT1 | P30419 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.34 |
| ▸ | ACVR1B | P36896 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310524 | 0.91 | BRD4 (0.37) | BRD4 | |
| SCHEMBL24309866 | 0.86 | FLT3 (0.36) | LTA4HFLT3HTR3EHTR3BADRB1 | |
| SCHEMBL24309698 | 0.85 | CDK4 (0.37) | LTA4HFLT3HTR3EHTR3BADRB1 | |
| SCHEMBL24309667 | 0.84 | FLT3 (0.36) | LTA4HFLT3MAPK10TGFBR1PIM1 | |
| SCHEMBL24310587 | 0.84 | FLT3 (0.37) | LTA4HFLT3HTR3EHTR3BADRB1 | |
| SCHEMBL24309516 | 0.84 | FLT3 (0.35) | LTA4HFLT3HTR3EHTR3BADRB1 | |
| SCHEMBL24309676 | 0.84 | FLT3 (0.38) | LTA4HFLT3MAPK10MAPK8TGFBR1 | |
| SCHEMBL24309787 | 0.83 | MAPT (0.36) | ALK | |
| SCHEMBL24309611 | 0.82 | CDK1 (0.34) | LTA4HFLT3HTR3EHTR3BADRB1 | |
| SCHEMBL24309513 | 0.81 | LTA4H (0.41) | LTA4HFLT3HTR3EHTR3BADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |