Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 4/20 | 0.35 |
| ▸ | ADRB1 | P08588 | 3/20 | 0.34 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.34 |
| ▸ | HTR3B | O95264 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.34 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.33 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.33 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.33 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309516 | 0.90 | FLT3 (0.35) | FLT3LTA4HADRB1HTR3EHTR3B | |
| SCHEMBL24309743 | 0.86 | LTA4H (0.41) | FLT3LTA4HADRB1HTR3EHTR3B | |
| SCHEMBL24310587 | 0.85 | FLT3 (0.37) | FLT3LTA4HADRB1HTR3EHTR3B | |
| SCHEMBL24309676 | 0.84 | FLT3 (0.38) | FLT3LTA4HACVR1HTR1AHTR7 | |
| SCHEMBL26807728 | 0.82 | FLT3 (0.37) | FLT3LTA4HACVR1HTR1ADRD2 | |
| SCHEMBL24309698 | 0.82 | CDK4 (0.37) | FLT3LTA4HADRB1HTR3EHTR3B | |
| SCHEMBL24310026 | 0.80 | ACVR1 (0.32) | LTA4HADRB1HTR3EHTR3BHTR3A | |
| SCHEMBL24309667 | 0.80 | FLT3 (0.36) | FLT3LTA4HACVR1HTR7TGFBR1 | |
| SCHEMBL24309611 | 0.79 | CDK1 (0.34) | FLT3LTA4HADRB1HTR3EHTR3B | |
| SCHEMBL24309732 | 0.79 | LTA4H (0.35) | FLT3LTA4HACVR1TGFBR1MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |