Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 4/20 | 0.36 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 4/20 | 0.34 |
| ▸ | ACVR1 | Q04771 | 4/20 | 0.34 |
| ▸ | TNK2 | Q07912 | 2/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | HTR3B | O95264 | 1/20 | 0.33 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.33 |
| ▸ | HTR3A | P46098 | 1/20 | 0.33 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.33 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309516 | 0.93 | FLT3 (0.35) | FLT3LTA4HMAPK10MAPK8TGFBR1 | |
| SCHEMBL24309676 | 0.91 | FLT3 (0.38) | FLT3LTA4HMAP4K1MAPK10MAPK8 | |
| SCHEMBL24310202 | 0.91 | PLK4 (0.38) | MAP4K1 | |
| SCHEMBL24310395 | 0.90 | HTR3A (0.39) | ACVR1HTR2CHTR3EHTR3BADRB1 | |
| SCHEMBL24309611 | 0.90 | CDK1 (0.34) | FLT3LTA4HMAPK10MAPK8TGFBR1 | |
| SCHEMBL24309350 | 0.89 | HTR3A (0.33) | ACVR1HTR2CHTR3EHTR3BADRB1 | |
| SCHEMBL24310785 | 0.89 | MAP4K1 (0.34) | MAP4K1MAPK8JAK3PIM1 | |
| SCHEMBL24310548 | 0.88 | PLK4 (0.36) | MAP4K1MAPK10 | |
| SCHEMBL24309667 | 0.86 | FLT3 (0.36) | FLT3LTA4HMAPK10TGFBR1ACVR1 | |
| SCHEMBL24310347 | 0.86 | GPR39 (0.39) | TNK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |