Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 3/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.33 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.33 |
| ▸ | WEE1 | P30291 | 2/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 3/20 | 0.33 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.32 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.32 |
| ▸ | LCK | P06239 | 2/20 | 0.32 |
| ▸ | GUSB | P08236 | 1/20 | 0.32 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.32 |
| ▸ | HTR7 | P34969 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24309676 | 0.89 | FLT3 (0.38) | FLT3LTA4HACVR1MAPK10TGFBR1 | |
| SCHEMBL24310587 | 0.86 | FLT3 (0.37) | FLT3LTA4HPIM1PIM3PIM2 | |
| SCHEMBL24309743 | 0.84 | LTA4H (0.41) | FLT3LTA4HPIM1BRD4ACVR1 | |
| SCHEMBL29566865 | 0.84 | GUSB (0.39) | FLT3LTA4HPIM1PIM3PIM2 | |
| SCHEMBL24309665 | 0.84 | GUSB (0.39) | FLT3LTA4HPIM1PIM3PIM2 | |
| SCHEMBL24309516 | 0.83 | FLT3 (0.35) | FLT3LTA4HBRD4ACVR1MAPK10 | |
| SCHEMBL24309611 | 0.83 | CDK1 (0.34) | FLT3LTA4HACVR1MAPK10TGFBR1 | |
| SCHEMBL24309350 | 0.81 | HTR3A (0.33) | PIM1PIM3PIM2WEE1ACVR1 | |
| SCHEMBL24309866 | 0.80 | FLT3 (0.36) | FLT3LTA4HBRD4ACVR1MAPK10 | |
| SCHEMBL24309698 | 0.79 | CDK4 (0.37) | FLT3LTA4HTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |