Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310706 | 0.85 | ALDH1A1 (0.33) | ALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL24309791 | 0.83 | AXL (0.33) | — | |
| SCHEMBL24309898 | 0.83 | ALDH1A1 (0.31) | ALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL24310412 | 0.83 | RORC (0.32) | — | |
| SCHEMBL24309878 | 0.82 | PIK3CD (0.34) | ALDH1A1HTT | |
| SCHEMBL24310222 | 0.81 | KDM5B (0.30) | KDM5BALDH1A1HTTSMN1; SMN2L3MBTL1 | |
| SCHEMBL24309833 | 0.75 | JAK2 (0.32) | — | |
| SCHEMBL24310591 | 0.74 | PDE10A (0.31) | — | |
| SCHEMBL24309815 | 0.72 | JAK2 (0.34) | — | |
| SCHEMBL24309731 | 0.70 | HTR1A (0.38) | ALDH1A1HTTSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |