Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | JAK3 | P52333 | 1/20 | 0.32 |
| ▸ | USP1 | O94782 | 1/20 | 0.31 |
| ▸ | FLT4 | P35916 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24310652 | 0.83 | KDM5B (0.30) | — | |
| SCHEMBL24309833 | 0.81 | JAK2 (0.32) | JAK1 | |
| SCHEMBL24309850 | 0.80 | AXL (0.35) | AXLJAK1JAK3USP1FLT4 | |
| SCHEMBL24309360 | 0.78 | DHFR (0.31) | — | |
| SCHEMBL24309372 | 0.78 | HTR1A (0.42) | JAK1JAK3USP1FLT4KDR | |
| SCHEMBL24309723 | 0.77 | JAK2 (0.34) | AXLJAK1 | |
| SCHEMBL24309815 | 0.77 | JAK2 (0.34) | AXLJAK1 | |
| SCHEMBL24309763 | 0.76 | USP1 (0.33) | AXLJAK1JAK3USP1 | |
| SCHEMBL24309836 | 0.75 | JAK2 (0.33) | JAK1JAK3 | |
| SCHEMBL24310706 | 0.73 | ALDH1A1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |