Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.36 |
| ▸ | JAK1 | P23458 | 3/20 | 0.36 |
| ▸ | TYK2 | P29597 | 3/20 | 0.36 |
| ▸ | STAT3 | P40763 | 3/20 | 0.36 |
| ▸ | JAK3 | P52333 | 3/20 | 0.36 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.33 |
| ▸ | USP1 | O94782 | 1/20 | 0.30 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.30 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.30 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.30 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.30 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.30 |
| ▸ | KDR | P35968 | 1/20 | 0.30 |
| ▸ | PDE1A | P54750 | 1/20 | 0.30 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.30 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.30 |
| ▸ | AXL | P30530 | 1/20 | 0.30 |
| ▸ | HTR1A | P08908 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | HTR7 | P34969 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29567319 | 0.82 | HTR1A (0.43) | JAK2JAK1TYK2STAT3JAK3 | |
| SCHEMBL24310670 | 0.82 | HTR1A (0.43) | JAK2JAK1TYK2STAT3JAK3 | |
| SCHEMBL24309764 | 0.82 | USP1 (0.32) | JAK1JAK3USP1PDE1APDE1B | |
| SCHEMBL24309663 | 0.82 | GPR39 (0.37) | JAK1JAK3AXL | |
| SCHEMBL24309850 | 0.79 | AXL (0.35) | JAK1JAK3USP1KDRAXL | |
| SCHEMBL24309763 | 0.78 | USP1 (0.33) | JAK1JAK3USP1AXL | |
| SCHEMBL24309345 | 0.76 | JAK1 (0.32) | JAK1JAK3USP1AXLHTR1A | |
| SCHEMBL24310657 | 0.76 | AXL (0.31) | JAK1JAK3USP1AXL | |
| SCHEMBL24309346 | 0.76 | — | — | |
| SCHEMBL24309801 | 0.73 | DRD2 (0.31) | JAK2JAK3DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022076627-A1 | MODULATORS OF CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-04-14 | — | — | WO | disclosed |