Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.54 |
| ▸ | CYTH2 | Q99418 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | IL1RN | P18510 | 1/20 | 0.49 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.49 |
| ▸ | ACLY | P53396 | 1/20 | 0.48 |
| ▸ | TCF4 | P15884 | 2/20 | 0.48 |
| ▸ | CTNNB1 | P35222 | 2/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16469750 | 0.88 | CA12 (0.51) | KDM4EKMT2ATCF4CTNNB1MEN1 | |
| SCHEMBL16489168 | 0.87 | KDM4E (0.47) | KDM4ETCF4CTNNB1ALDH1A1GAA | |
| SCHEMBL16470520 | 0.86 | NHERF1 (0.51) | KDM4ETCF4CTNNB1ALDH1A1 | |
| SCHEMBL16469850 | 0.86 | KDM4E (0.49) | KDM4ETCF4CTNNB1ALDH1A1GAA | |
| SCHEMBL16469306 | 0.86 | ALDH1A1 (0.52) | KDM4EKMT2ATCF4CTNNB1MEN1 | |
| SCHEMBL22017159 | 0.85 | FFAR4 (0.59) | FFAR4CYTH2KMT2AIL1RNKEAP1 | |
| SCHEMBL16528885 | 0.83 | FFAR4 (0.58) | FFAR4KDM4EKMT2AHSD17B10MEN1 | |
| SCHEMBL28058154 | 0.82 | TDP1 (0.62) | KDM4EKMT2AMEN1ALDH1A1PKM | |
| SCHEMBL8249331 | 0.81 | KDM4E (0.70) | CYTH2KDM4EKMT2AIL1RNKEAP1 | |
| SCHEMBL16470200 | 0.81 | CYP3A4 (0.50) | KDM4ETCF4CTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220119383-A1 | QUINOLINE DERIVATIVES AS ALPHA4BETA7 INTEGRIN INHIBITORS | GILEAD SCIENCES, INC. | 2022-04-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220119383-A1 | QUINOLINE DERIVATIVES AS ALPHA4BETA7 INTEGRIN INHIBITORS | ITGB7, ITGB1, ITGA2B | FFAR4 1263/4885CYTH2 1396/4885KDM4E 1390/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.