Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 4/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.33 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.33 |
| ▸ | PLG | P00747 | 1/20 | 0.32 |
| ▸ | PLAU | P00749 | 1/20 | 0.32 |
| ▸ | PLAT | P00750 | 1/20 | 0.32 |
| ▸ | CDK1 | P06493 | 2/20 | 0.32 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.32 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
| ▸ | BACE1 | P56817 | 1/20 | 0.31 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.31 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.31 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2428718 | 0.87 | CYP3A4 (0.32) | GRM4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL2430722 | 0.86 | PIK3CD (0.38) | GRM4PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL1244115 | 0.86 | PIK3CD (0.47) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL3302945 | 0.81 | GPR119 (0.37) | RORC | |
| SCHEMBL2427449 | 0.81 | PIK3CD (0.38) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL13433609 | 0.78 | MCL1 (0.38) | USP30PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL1273640 | 0.78 | RXFP1 (0.42) | RORC | |
| SCHEMBL3305623 | 0.76 | NCEH1 (0.40) | RORC | |
| SCHEMBL1072580 | 0.76 | RAB9A (0.36) | PIK3CDPIK3CAPIK3CBPIK3CGBACE1 | |
| SCHEMBL3302407 | 0.75 | GPR119 (0.36) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041159-B1 | MACROCYCLIC COMPOUNDS AS ANTIVIRAL AGENTS | ANGELETTI P IST RICHERCHE BIO (IT) | 2011-09-28 | — | — | EP | disclosed |