Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 12/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.34 |
| ▸ | F13A1 | P00488 | 1/20 | 0.33 |
| ▸ | TGM2 | P21980 | 1/20 | 0.33 |
| ▸ | TGM1 | P22735 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2430722 | 0.88 | PIK3CD (0.38) | PIK3CDPIK3CAPIK3CBPIK3CGIRAK4 | |
| SCHEMBL2428718 | 0.85 | CYP3A4 (0.32) | PIK3CDPIK3CAPIK3CBPIK3CGCYP3A4 | |
| SCHEMBL1072632 | 0.82 | SMN1; SMN2 (0.36) | PIK3CDPIK3CAPIK3CBPIK3CGPDE4B | |
| SCHEMBL3302407 | 0.81 | GPR119 (0.36) | — | |
| SCHEMBL2431240 | 0.81 | RORC (0.35) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL1074490 | 0.81 | CYP3A4 (0.40) | PIK3CDPIK3CAPIK3CBPIK3CGIRAK4 | |
| SCHEMBL1074488 | 0.81 | CYP3A4 (0.40) | PIK3CDPIK3CAPIK3CBPIK3CGIRAK4 | |
| SCHEMBL1071024 | 0.80 | PDE4B (0.33) | PIK3CDPIK3CAPIK3CBPIK3CGPDE4B | |
| SCHEMBL16318484 | 0.79 | CYP3A4 (0.41) | PIK3CDPIK3CAPIK3CBPIK3CGIRAK4 | |
| SCHEMBL16318483 | 0.79 | CYP3A4 (0.41) | PIK3CDPIK3CAPIK3CBPIK3CGIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041159-B1 | MACROCYCLIC COMPOUNDS AS ANTIVIRAL AGENTS | ANGELETTI P IST RICHERCHE BIO (IT) | 2011-09-28 | — | — | EP | disclosed |