Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 2/20 | 0.38 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 11/20 | 0.36 |
| ▸ | APAF1 | O14727 | 1/20 | 0.34 |
| ▸ | TDP2 | O95551 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.34 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.34 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.34 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.34 |
| ▸ | GRM4 | Q14833 | 2/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 3/20 | 0.33 |
| ▸ | CDK9 | P50750 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2427449 | 0.88 | PIK3CD (0.38) | PIK3CDPIK3CAPIK3CBPIK3CGIRAK4 | |
| SCHEMBL2431240 | 0.86 | RORC (0.35) | PIK3CDPIK3CAPIK3CBPIK3CGGRM4 | |
| SCHEMBL1072461 | 0.81 | SMN1; SMN2 (0.35) | PIK3CDPIK3CAPIK3CBPIK3CG | |
| SCHEMBL2428718 | 0.81 | CYP3A4 (0.32) | PIK3CDPIK3CAPIK3CBPIK3CGGRM4 | |
| SCHEMBL3302945 | 0.80 | GPR119 (0.37) | — | |
| SCHEMBL1070509 | 0.80 | PIK3CD (0.39) | PIK3CDPIK3CAPIK3CBPIK3CGIRAK4 | |
| SCHEMBL1070436 | 0.78 | PDE4B (0.34) | — | |
| SCHEMBL16318728 | 0.77 | CCNT1 (0.42) | PIK3CDPIK3CAPIK3CBPIK3CGIRAK4 | |
| SCHEMBL16318729 | 0.77 | CCNT1 (0.42) | PIK3CDPIK3CAPIK3CBPIK3CGIRAK4 | |
| SCHEMBL1072580 | 0.76 | RAB9A (0.36) | PIK3CDPIK3CAPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041159-B1 | MACROCYCLIC COMPOUNDS AS ANTIVIRAL AGENTS | ANGELETTI P IST RICHERCHE BIO (IT) | 2011-09-28 | — | — | EP | disclosed |