Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | PDE2A | O00408 | 2/20 | 0.34 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.34 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.33 |
| ▸ | LMNA | P02545 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24654673 | 0.84 | MAPT (0.40) | HPGDTHRBKDM4ETDP1MAPK1 | |
| SCHEMBL24313196 | 0.84 | HTR2A (0.39) | HTTKDM4ETDP1MEN1KMT2A | |
| SCHEMBL24654606 | 0.83 | MEN1 (0.38) | MAPK1MEN1KMT2ATSHRCYSLTR2 | |
| SCHEMBL24313210 | 0.78 | L3MBTL1 (0.43) | HPGDTHRBKDM4ETDP1MAPK1 | |
| SCHEMBL22028461 | 0.77 | ALDH1A1 (0.38) | HPGDHTTTHRBTDP1MAPK1 | |
| SCHEMBL24313197 | 0.76 | RORC (0.48) | HPGDTDP1MAPK1MEN1KMT2A | |
| SCHEMBL24313107 | 0.75 | CASR (0.33) | HPGDMEN1KMT2APDE2AP2RX7 | |
| SCHEMBL24313117 | 0.75 | CASR (0.33) | HPGDMEN1KMT2APDE2AP2RX7 | |
| SCHEMBL24313116 | 0.74 | GLA (0.36) | HTTKDM4ETDP1MEN1KMT2A | |
| SCHEMBL24313254 | 0.74 | AR (0.35) | HPGDHTTKDM4ETSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4043460-A1 | ANTIPROLIFERATION COMPOUNDS AND USES THEREOF | Merck Patent GmbH (DE) | 2022-08-17 | — | — | EP | disclosed |
| EP-3784666-B1 | ANTIPROLIFERATION COMPOUNDS AND USES THEREOF | MERCK PATENT GMBH (DE) | 2022-03-16 | — | — | EP | disclosed |