Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.41 |
| ▸ | MMP2 | P08253 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.39 |
| ▸ | FBP1 | P09467 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31723093 | 1.00 | TAS1R3 (0.42) | TAS1R3TAS1R1ALDH1A1LMNATHRB | |
| SCHEMBL31723078 | 0.92 | ALDH1A1 (0.43) | ALDH1A1LMNATHRBPTGER4MMP2 | |
| SCHEMBL31723097 | 0.90 | ALDH1A1 (0.41) | ALDH1A1LMNATHRBPTGER4MMP2 | |
| SCHEMBL24313971 | 0.90 | ALDH1A1 (0.41) | ALDH1A1LMNATHRBPTGER4MMP2 | |
| SCHEMBL24313791 | 0.84 | KDM4E (0.51) | ALDH1A1LMNAPTGER4MEN1NPC1 | |
| SCHEMBL31723074 | 0.84 | KDM4E (0.51) | ALDH1A1LMNAPTGER4MEN1NPC1 | |
| SCHEMBL22601043 | 0.84 | PTGER4 (0.48) | ALDH1A1PTGER4MMP2MEN1NPC1 | |
| SCHEMBL22588190 | 0.83 | MAPT (0.48) | ALDH1A1LMNAPTGER4MEN1NPC1 | |
| SCHEMBL22588427 | 0.83 | BCAT1 (0.43) | ALDH1A1LMNAPTGER4MMP2MEN1 | |
| SCHEMBL30538408 | 0.83 | BCAT1 (0.55) | ALDH1A1LMNATHRBMMP2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |