Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HPGDS | O60760 | 5/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP9 | P14780 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24313800 | 0.87 | LMNA (0.46) | LMNAHPGDSMAPK1HTTL3MBTL1 | |
| SCHEMBL2001821 | 0.82 | HPGDS (0.51) | HPGDSMAPK1MMP2MMP9MMP8 | |
| SCHEMBL24313798 | 0.79 | LIPE (0.43) | LMNAHPGDSMAPK1PDE4BSCN9A | |
| SCHEMBL21838860 | 0.76 | LMNA (0.65) | LMNAMAPK1TSHRL3MBTL1KDM4E | |
| SCHEMBL23474086 | 0.76 | LMNA (0.52) | LMNAMAPK1TSHRL3MBTL1KDM4E | |
| SCHEMBL30617764 | 0.74 | HTT (0.52) | HPGDSMAPK1MMP2MMP9MMP8 | |
| SCHEMBL25255029 | 0.74 | HTT (0.52) | HPGDSMAPK1MMP2MMP9MMP8 | |
| SCHEMBL23474167 | 0.74 | LMNA (0.41) | LMNATHRBMAPK1MMP2MMP9 | |
| SCHEMBL4596324 | 0.73 | LMNA (0.52) | LMNAMAPK1TSHRL3MBTL1KDM4E | |
| SCHEMBL3586183 | 0.73 | LMNA (0.60) | LMNAMAPK1TSHRL3MBTL1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022077161-A1 | COMPOUNDS FOR MODULATING ACTIVITY OF FXR AND USES THEREOF | GANNEX PHARMA CO., LTD. (CN) | 2022-04-21 | — | — | WO | disclosed |
| CN-114315815-A | Compounds for modulating FXR activity and uses thereof | 甘莱制药有限公司 | 2022-04-12 | — | — | CN | disclosed |