Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.48 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.48 |
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.47 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24314185 | 0.89 | KDM4E (0.47) | KDM4EPKMCSF1RTGFBR1GPR119 | |
| SCHEMBL16688907 | 0.88 | MEN1 (0.50) | KDM4EPKMCSF1RGPR119 | |
| SCHEMBL19430661 | 0.87 | KDM4E (0.47) | KDM4EPKMCSF1RGPR119CHEK2 | |
| SCHEMBL24313742 | 0.86 | TGFBR1 (0.49) | KDM4EPKMCSF1RTGFBR1GPR119 | |
| SCHEMBL24313740 | 0.86 | CHEK2 (0.45) | KDM4EPKMCSF1RTGFBR1GPR119 | |
| SCHEMBL30988946 | 0.85 | KDM4E (0.55) | KDM4EPKMCSF1RTGFBR1GPR119 | |
| SCHEMBL24333408 | 0.84 | KDM4E (0.46) | KDM4EPKMCSF1RTGFBR1GPR119 | |
| SCHEMBL20536605 | 0.81 | MGLL (0.47) | KDM4EPKMCSF1RGPR119CHEK2 | |
| SCHEMBL16688916 | 0.81 | USP30 (0.50) | KDM4EPKMCSF1RGPR119CHEK2 | |
| SCHEMBL9014080 | 0.81 | GPR119 (0.50) | KDM4EPKMCSF1RTGFBR1GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |