Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 13/20 | 0.45 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.42 |
| ▸ | FEN1 | P39748 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24333408 | 0.88 | KDM4E (0.46) | CHEK2KDM4EPKMGPR119TGFBR1 | |
| SCHEMBL24314186 | 0.86 | KDM4E (0.49) | CHEK2KDM4EPKMGPR119TGFBR1 | |
| SCHEMBL24314185 | 0.84 | KDM4E (0.47) | CHEK2KDM4EPKMGPR119TGFBR1 | |
| SCHEMBL24313742 | 0.84 | TGFBR1 (0.49) | CHEK2KDM4EPKMGPR119TGFBR1 | |
| SCHEMBL24314284 | 0.82 | RIPK1 (0.41) | KDM4E | |
| SCHEMBL20536605 | 0.77 | MGLL (0.47) | CHEK2KDM4EPKMGPR119CSF1R | |
| SCHEMBL3111680 | 0.76 | RBP4 (0.67) | KDM4EPKMGPR119CSF1RALOX5AP | |
| SCHEMBL3108299 | 0.76 | RBP4 (0.63) | KDM4EPKMGPR119CSF1R | |
| SCHEMBL3505728 | 0.76 | MGLL (0.48) | CHEK2KDM4EPKMGPR119CSF1R | |
| SCHEMBL13419698 | 0.76 | GPR119 (0.50) | CHEK2KDM4EPKMGPR119CSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |