Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 11/20 | 0.39 |
| ▸ | HTR2B | P41595 | 6/20 | 0.39 |
| ▸ | HTR2A | P28223 | 4/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | NOS1 | P29475 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24313740 | 0.82 | CHEK2 (0.45) | KDM4E | |
| SCHEMBL24334343 | 0.80 | KDM4E (0.54) | RIPK1HTR2CHTR2BHTR2AKDM4E | |
| SCHEMBL24313928 | 0.78 | CA1 (0.37) | CYP2C19KDM4EALDH1A1HSD17B10 | |
| SCHEMBL20206824 | 0.78 | RIPK1 (0.44) | RIPK1HTR2CHTR2BHTR2AKDM4E | |
| SCHEMBL29469863 | 0.78 | RIPK1 (0.44) | RIPK1HTR2CHTR2BHTR2ACYP2C19 | |
| SCHEMBL24314287 | 0.78 | RIPK1 (0.44) | RIPK1HTR2CHTR2BHTR2ACYP2C19 | |
| SCHEMBL24313917 | 0.77 | PDE4B (0.38) | RIPK1HTR2CHTR2BHTR2A | |
| SCHEMBL24313794 | 0.77 | KDM4E (0.41) | CYP2C19KDM4ECNR2ALDH1A1HSD17B10 | |
| SCHEMBL22588350 | 0.76 | ALDH1A1 (0.47) | RIPK1ALDH1A1HSD17B10 | |
| SCHEMBL20347948 | 0.76 | RIPK1 (0.45) | RIPK1HTR2CHTR2BHTR2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081842-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| WO-2022081807-A1 | SUBSTITUTED ACYL SULFONAMIDES FOR TREATING CANCER | THE BROAD INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |