SCHEMBL2431457

SCHEMBL2431457

CCCCCCCCCc1ccc(C(=O)Oc2ccc(OC(=O)c3ccc(OCCCCCCOC4CCCCO4)cc3)cc2)cc1

nearest known ligand 0.62

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.62
MEN1 O00255 1/20 0.62
NPC1 O15118 3/20 0.50
LMNA P02545 3/20 0.50
SMN1; SMN2 Q16637 3/20 0.50
NFKB1 P19838 3/20 0.50
NFKB2 Q00653 3/20 0.50
RELA Q04206 3/20 0.50
CYP1A2 P05177 1/20 0.48
CYP3A4 P08684 1/20 0.48
CYP2D6 P10635 1/20 0.48
CYP2C9 P11712 1/20 0.48
CYP2C19 P33261 1/20 0.48
PRSS1 P07477 1/20 0.46
ACR P10323 1/20 0.46
MAPT P10636 3/20 0.45
POLB P06746 1/20 0.44
THRA P10827 1/20 0.44
THRB P10828 1/20 0.44
TP53 P04637 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1531938 0.89 KMT2A (0.78) KMT2AMEN1NPC1LMNASMN1; SMN2
SCHEMBL12768363 0.89 KMT2A (0.78) KMT2AMEN1NPC1LMNASMN1; SMN2
SCHEMBL28387481 0.88 MEN1 (0.53) KMT2AMEN1NPC1LMNASMN1; SMN2
SCHEMBL1531762 0.86 KMT2A (0.59) KMT2AMEN1NPC1LMNASMN1; SMN2
SCHEMBL13572552 0.86 KMT2A (0.70) KMT2AMEN1NPC1LMNASMN1; SMN2
SCHEMBL13531297 0.86 KMT2A (0.70) KMT2AMEN1NPC1LMNASMN1; SMN2
SCHEMBL221305 0.86 KMT2A (0.70) KMT2AMEN1NPC1LMNASMN1; SMN2
SCHEMBL12768510 0.86 KMT2A (0.70) KMT2AMEN1NPC1LMNASMN1; SMN2
SCHEMBL1531771 0.86 MEN1 (0.73) KMT2AMEN1NPC1LMNASMN1; SMN2
SCHEMBL8625773 0.85 NPC1 (0.55) KMT2ANPC1LMNASMN1; SMN2NFKB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3673521-B1 DIELECTRIC LAYER COMPRISING COPOLYMER WITH MESOGENIC UNITS PPG IND OHIO INC (US) 2023-08-09 EP disclosed
CN-111033777-B Dielectric layer comprising copolymer with mesogenic units PPG工业俄亥俄公司 2023-08-08 CN disclosed
US-11525087-B2 Dielectric devices and methods of fabrication PPG INDUSTRIES OHIO, INC. (US) 2022-12-13 US disclosed
US-20200263092-A1 DIELECTRIC DEVICES AND METHODS OF FABRICATION PPG INDUSTRIES OHIO, INC. 2020-08-20 US disclosed
EP-3673521-A1 DIELECTRIC LAYER COMPRISING COPOLYMER WITH MESOGENIC UNITS PPG Industries Ohio, Inc. (US) 2020-07-01 EP disclosed
CN-111033777-A Dielectric layer comprising copolymer with mesogenic units PPG工业俄亥俄公司 2020-04-17 CN disclosed
US-10619099-B2 Dielectric devices and methods of fabrication PPG INDUSTRIES OHIO, INC. (US) 2020-04-14 US disclosed
WO-2019040934-A1 DIELECTRIC LAYER COMPRISING COPOLYMER WITH MESOGENIC UNITS PPG INDUSTRIES OHIO, INC. (US) 2019-02-28 WO disclosed
EP-2686401-B9 MESOGEN-CONTAINING COMPOUNDS TRANSITIONS OPTICAL INC (US) 2017-05-31 EP disclosed
EP-2686401-B1 MESOGEN-CONTAINING COMPOUNDS TRANSITIONS OPTICAL INC (US) 2016-11-23 EP disclosed
EP-2686401-A1 MESOGEN-CONTAINING COMPOUNDS Transitions Optical, Inc. (US) 2014-01-22 EP disclosed
US-8628685-B2 Mesogen-containing compounds TRANSITIONS OPTICAL, INC (US) 2014-01-14 US disclosed
WO-2012128944-A1 MESOGEN-CONTAINING COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2012-09-27 WO disclosed
US-20110216273-A1 MESOGEN-CONTAINING COMPOUNDS TRANSITIONS OPTICAL, INC. (US) 2011-09-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110216273-A1 MESOGEN-CONTAINING COMPOUNDS BMP2, MYOC, RARG KMT2A 4018/4885MEN1 130/4885NPC1 4115/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.