Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCQ | Q04759 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 3/20 | 0.42 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
| ▸ | HTR3A | P46098 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.39 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | FURIN | P09958 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28630760 | 0.94 | HDAC3 (0.46) | HDAC3HRH4HRH3HTR3ARAB9A | |
| SCHEMBL25666898 | 0.86 | MAPT (0.44) | HDAC3HRH3RAB9AHDAC2 | |
| SCHEMBL24315986 | 0.85 | SMO (0.44) | PRKCQHDAC3RAB9AL3MBTL1HDAC1 | |
| SCHEMBL14658665 | 0.84 | MAPT (0.45) | HDAC3HRH3RAB9AL3MBTL1HDAC2 | |
| SCHEMBL30855580 | 0.84 | MAPT (0.45) | HDAC3HRH3RAB9AL3MBTL1HDAC2 | |
| SCHEMBL30499441 | 0.83 | HDAC3 (0.46) | HDAC3HRH4HTR3ARAB9AL3MBTL1 | |
| SCHEMBL24026553 | 0.81 | KCNJ1 (0.49) | HDAC3HRH4HTR3ARAB9AL3MBTL1 | |
| SCHEMBL877503 | 0.78 | HRH3 (0.43) | HRH3 | |
| SCHEMBL5207636 | 0.78 | RAB9A (0.53) | HDAC3HRH3RAB9AL3MBTL1HDAC2 | |
| SCHEMBL25307325 | 0.78 | KCNJ1 (0.51) | HRH3RAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081872-A1 | JANUS KINASE INHIBITORS | GB008, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| WO-2022081872-A1 | JANUS KINASE INHIBITORS | GB008, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| US-9585884-B2 | Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2 | AUSPEX PHARMACEUTICALS, INC. (US) | 2017-03-07 | — | — | US | disclosed |