Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 7/20 | 0.39 |
| ▸ | MAOA | P21397 | 6/20 | 0.39 |
| ▸ | MAOB | P27338 | 6/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | SSTR3 | P32745 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27010655 | 0.91 | ALDH1A1 (0.39) | KDM1AMAOAMAOBALDH1A1KDM4E | |
| SCHEMBL26620804 | 0.82 | ALDH1A1 (0.41) | KDM1AMAOAMAOBALDH1A1KDM4E | |
| SCHEMBL27010657 | 0.78 | ALDH1A1 (0.36) | KDM1AMAOAMAOBALDH1A1KDM4E | |
| SCHEMBL26620805 | 0.76 | ALDH1A1 (0.39) | KDM1AMAOAMAOBALDH1A1KDM4E | |
| SCHEMBL27010653 | 0.68 | TRPV3 (0.39) | KDM1AMAOAMAOBALDH1A1KDM4E | |
| SCHEMBL27010696 | 0.68 | SLC18A3 (0.35) | — | |
| SCHEMBL30674935 | 0.67 | ALDH1A1 (0.42) | ALDH1A1KDM4ETSHRPOLBMEN1 | |
| SCHEMBL27414693 | 0.67 | TUBB4A (0.38) | KDM4E | |
| SCHEMBL24316213 | 0.67 | TSHR (0.43) | ALDH1A1KDM4ELMNATSHRSSTR3 | |
| SCHEMBL27010659 | 0.65 | KDM1A (0.47) | KDM1AMAOAMAOBALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022081925-A1 | TRICYCLIC LIGANDS FOR DEGRADATION OF IKZF2 OR IKZF4 | C4 THERAPEUTICS, INC. (US) | 2022-04-21 | — | — | WO | disclosed |
| US-9585884-B2 | Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2 | AUSPEX PHARMACEUTICALS, INC. (US) | 2017-03-07 | — | — | US | disclosed |