Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.49 |
| ▸ | HTR1A | P08908 | 4/20 | 0.47 |
| ▸ | DRD2 | P14416 | 4/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 11/20 | 0.47 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.46 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.45 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.45 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.45 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.45 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.45 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.43 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24316412 | 0.87 | CYP11B1 (0.48) | DRD2ALOX5CYP11B1CYP11B2 | |
| SCHEMBL24316421 | 0.85 | CALM1 (0.47) | TAAR1CYP11B1CYP11B2 | |
| SCHEMBL24316417 | 0.77 | TAAR1 (0.47) | TAAR1ABCB1ALOX5 | |
| SCHEMBL24316419 | 0.76 | PDGFRB (0.49) | HTR1AMAOB | |
| SCHEMBL21327653 | 0.75 | CSF1R (0.54) | MAOB | |
| SCHEMBL24316986 | 0.74 | KDM4E (0.50) | HTR1AMAOB | |
| SCHEMBL27717492 | 0.73 | TAAR1 (0.61) | TAAR1HTR1ADRD2ABCB1CHRM2 | |
| SCHEMBL30682056 | 0.71 | CSF1R (0.42) | TAAR1 | |
| SCHEMBL27968568 | 0.71 | GABRA1 (0.81) | TAAR1HTR1ADRD2ABCB1GABRA1 | |
| SCHEMBL29079537 | 0.71 | AKR1B1 (0.62) | TAAR1HTR1ADRD2ABCB1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022057895-A1 | HETEROAROMATIC COMPOUNDS AND USES THEREOF | HUTCHISON MEDIPHARMA LIMITED (CN) | 2022-03-24 | — | — | WO | disclosed |
| US-9585884-B2 | Pyrimidinone inhibitors of lipoprotein-associated phospholipase A2 | AUSPEX PHARMACEUTICALS, INC. (US) | 2017-03-07 | — | — | US | disclosed |