Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 3/20 | 0.38 |
| ▸ | GBA1 | P04062 | 2/20 | 0.37 |
| ▸ | GNAO1 | P09471 | 4/20 | 0.36 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.35 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.35 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.33 |
| ▸ | SCN1A | P35498 | 1/20 | 0.33 |
| ▸ | SCN4A | P35499 | 1/20 | 0.33 |
| ▸ | SCN7A | Q01118 | 1/20 | 0.33 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.33 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.33 |
| ▸ | SCN11A | Q9UI33 | 1/20 | 0.33 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.33 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24319185 | 0.81 | NCF1 (0.39) | ACHEGNAO1CACNA2D1CACNA1BCACNB1 | |
| SCHEMBL24319509 | 0.77 | ACHE (0.35) | ACHECHRM5ADRA2CSIGMAR1SCN1A | |
| SCHEMBL14422030 | 0.77 | GBA1 (0.48) | ACHEGBA1GNAO1CACNA2D1CACNA1B | |
| SCHEMBL25134177 | 0.76 | GBA1 (0.37) | ACHEGBA1GNAO1CACNA2D1CACNA1B | |
| SCHEMBL13661595 | 0.76 | ACHE (0.64) | ACHEGBA1GNAO1CACNA2D1CACNA1B | |
| SCHEMBL24414411 | 0.75 | ACHE (0.40) | ACHEGBA1GNAO1CACNA2D1CACNA1B | |
| SCHEMBL2570307 | 0.75 | GBA1 (0.47) | ACHEGBA1GNAO1CACNA2D1CACNA1B | |
| Hydrochloric Acid SCHEMBL5573130 | 0.75 | GBA1 (0.47) | ACHEGBA1GNAO1CACNA2D1CACNA1B | |
| SCHEMBL24319650 | 0.75 | CACNA2D1 (0.37) | ACHEGBA1GNAO1CACNA2D1CACNA1B | |
| SCHEMBL18314648 | 0.74 | LMNA (0.33) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022047145-A1 | RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-03-03 | — | — | WO | disclosed |