Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | RAD52 | P43351 | 1/20 | 0.31 |
| ▸ | GFER | P55789 | 1/20 | 0.31 |
| ▸ | CCR2 | P41597 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26705159 | 0.91 | CHRM5 (0.39) | CHRM5ADRA2CACHECCR2KCNH2 | |
| SCHEMBL22047347 | 0.86 | ACHE (0.36) | ALDH1A1CHRM5ADRA2CACHECCR2 | |
| SCHEMBL24745088 | 0.84 | DRD2 (0.37) | CHRM5ADRA2CACHESMN1; SMN2 | |
| SCHEMBL18873649 | 0.84 | KCNH2 (0.43) | ALDH1A1KDM4ECHRM5ADRA2CACHE | |
| SCHEMBL26705153 | 0.82 | NCF1 (0.43) | CHRM5ADRA2CACHECCR2KCNH2 | |
| SCHEMBL12434924 | 0.81 | CHRM5 (0.52) | CHRM5ADRA2CACHESMN1; SMN2MAPT | |
| SCHEMBL12403098 | 0.81 | CHRM5 (0.46) | CHRM5ADRA2CACHECCR2KCNH2 | |
| SCHEMBL18873648 | 0.80 | NCF1 (0.46) | ALDH1A1KDM4ECHRM5ADRA2CACHE | |
| SCHEMBL25571696 | 0.80 | NCF1 (0.46) | CHRM5ADRA2CACHECCR2KCNH2 | |
| SCHEMBL19590887 | 0.79 | CHRM5 (0.56) | CHRM5ADRA2CACHESMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022047145-A1 | RAPIDLY ACCELERATING FIBROSARCOMA PROTEIN DEGRADING COMPOUNDS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. (US) | 2022-03-03 | — | — | WO | disclosed |