Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A3 | P47895 | 9/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.63 |
| ▸ | ALDH1A2 | O94788 | 1/20 | 0.63 |
| ▸ | NPC1 | O15118 | 10/20 | 0.59 |
| ▸ | RAB9A | P51151 | 10/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.59 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.59 |
| ▸ | PKM | P14618 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | TP53 | P04637 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.59 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.50 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24320032 | 0.84 | ALDH1A3 (0.63) | ALDH1A3ALDH1A1ALDH1A2NPC1RAB9A | |
| SCHEMBL13325936 | 0.81 | NPC1 (0.60) | ALDH1A3ALDH1A1ALDH1A2NPC1RAB9A | |
| SCHEMBL13325768 | 0.78 | ALDH1A3 (1.00) | ALDH1A3ALDH1A1ALDH1A2NPC1RAB9A | |
| SCHEMBL1987470 | 0.76 | NPC1 (0.96) | ALDH1A3ALDH1A1ALDH1A2NPC1RAB9A | |
| SCHEMBL2404662 | 0.75 | RAB9A (1.00) | ALDH1A3ALDH1A1ALDH1A2NPC1RAB9A | |
| SCHEMBL970456 | 0.75 | ALDH1A3 (0.69) | ALDH1A3ALDH1A1ALDH1A2NPC1RAB9A | |
| SCHEMBL6491308 | 0.75 | ALDH1A3 (0.69) | ALDH1A3ALDH1A1ALDH1A2NPC1RAB9A | |
| SCHEMBL27188296 | 0.75 | ALDH1A3 (0.69) | ALDH1A3ALDH1A1ALDH1A2NPC1RAB9A | |
| SCHEMBL29438982 | 0.75 | ALDH1A3 (0.79) | ALDH1A3ALDH1A1ALDH1A2NPC1RAB9A | |
| SCHEMBL13325747 | 0.73 | NPC1 (0.90) | ALDH1A3ALDH1A1ALDH1A2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116669769-A | Piperidinyl small molecule degradants of HELIOS and methods of use | 达纳－法伯癌症研究所公司 | 2023-08-29 | — | — | CN | disclosed |
| WO-2022081976-A1 | PIPERIDINYL SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |