Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | DPP4 | P27487 | 2/20 | 0.54 |
| ▸ | ATM | Q13315 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30516932 | 1.00 | ALDH1A1 (0.62) | ALDH1A1SMN1; SMN2DPP4ATMMAPT | |
| SCHEMBL9954930 | 0.86 | POLB (0.58) | ALDH1A1SMN1; SMN2DPP4ATMLMNA | |
| SCHEMBL9954958 | 0.85 | ALDH1A1 (0.47) | ALDH1A1SMN1; SMN2DPP4ATMMAPT | |
| SCHEMBL1963616 | 0.84 | SMN1; SMN2 (0.72) | ALDH1A1SMN1; SMN2DPP4LMNANPSR1 | |
| SCHEMBL30454814 | 0.84 | SMN1; SMN2 (0.72) | ALDH1A1SMN1; SMN2DPP4LMNANPSR1 | |
| SCHEMBL28478839 | 0.78 | DPP4 (0.44) | ALDH1A1SMN1; SMN2DPP4MAPTKMT2A | |
| SCHEMBL28485156 | 0.76 | ALDH1A1 (0.42) | ALDH1A1SMN1; SMN2DPP4MEN1KMT2A | |
| SCHEMBL7171020 | 0.76 | POLB (0.67) | SMN1; SMN2ATMMAPTLMNAHPGD | |
| SCHEMBL24320125 | 0.75 | MEN1 (0.52) | ALDH1A1SMN1; SMN2ATMLMNAMEN1 | |
| SCHEMBL30089874 | 0.75 | MAPT (0.69) | SMN1; SMN2ATMMAPTLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116669769-A | Piperidinyl small molecule degradants of HELIOS and methods of use | 达纳－法伯癌症研究所公司 | 2023-08-29 | — | — | CN | disclosed |
| WO-2022081976-A1 | PIPERIDINYL SMALL MOLECULE DEGRADERS OF HELIOS AND METHODS OF USE | DANA-FARBER CANCER INSTITUTE, INC. (US) | 2022-04-21 | — | — | WO | disclosed |