SCHEMBL24322009

SCHEMBL24322009

CN1CCN(C(=O)C2CCN(Cc3ccc(-n4c(O)nnc4-c4ccc(O)cc4O)cc3)CC2)CC1

nearest known ligand 0.54

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 1/20 0.44
▸ ALDH1A1 P00352 5/20 0.43
▸ KDM4E B2RXH2 4/20 0.43
▸ TDP1 Q9NUW8 2/20 0.43
▸ MEN1 O00255 3/20 0.41
▸ KMT2A Q03164 3/20 0.41
▸ TSHR P16473 2/20 0.41
▸ SMN1; SMN2 Q16637 2/20 0.41
▸ ALOX15 P16050 1/20 0.41
▸ MAPK1 P28482 1/20 0.41
▸ POLB P06746 1/20 0.40
▸ TP53 P04637 1/20 0.39
▸ MAPT P10636 1/20 0.39
▸ HTT P42858 1/20 0.39
▸ NPSR1 Q6W5P4 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24321161 0.89 L3MBTL1 (0.44) L3MBTL1ALDH1A1KDM4ETDP1MEN1
SCHEMBL24321134 0.86 HSP90AA1 (0.47) L3MBTL1ALDH1A1KDM4ETDP1MEN1
SCHEMBL24321211 0.85 ALDH1A1 (0.42) L3MBTL1ALDH1A1KDM4ETDP1MEN1
SCHEMBL24452615 0.79 HRH3 (0.41) MEN1KMT2A
SCHEMBL12642484 0.79 L3MBTL1 (0.60) L3MBTL1ALDH1A1KDM4ETDP1MEN1
SCHEMBL24321350 0.79 MEN1 (0.47) L3MBTL1ALDH1A1KDM4ETDP1MEN1
SCHEMBL24321184 0.78 HSP90AA1 (0.46) L3MBTL1ALDH1A1KDM4ETDP1MEN1
SCHEMBL16569200 0.78 KDM4E (0.42) L3MBTL1ALDH1A1KDM4ETDP1MEN1
SCHEMBL18561685 0.77 HSP90AA1 (0.40) L3MBTL1ALDH1A1KDM4ETDP1MEN1
SCHEMBL24321356 0.77 HSP90AA1 (0.45) L3MBTL1ALDH1A1KDM4ETDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022078414-A1 METHODS AND COMPOSITIONS FOR TARGETED PROTEIN DEGRADATION RANOK THERAPEUTICS (HANGZHOU) CO. LTD. (CN) 2022-04-21 — — WO disclosed
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