Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2793889 | 0.88 | KMT2A (0.77) | MEN1TSHRKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL14456826 | 0.84 | L3MBTL1 (0.57) | L3MBTL1MEN1TSHRKMT2A | |
| SCHEMBL8916029 | 0.82 | ALDH1A1 (0.73) | L3MBTL1MEN1TSHRKMT2AALDH1A1 | |
| SCHEMBL25499383 | 0.82 | L3MBTL1 (0.61) | L3MBTL1MEN1TSHRKMT2AALDH1A1 | |
| SCHEMBL24322009 | 0.79 | L3MBTL1 (0.44) | L3MBTL1MEN1TSHRKMT2AALDH1A1 | |
| SCHEMBL2477654 | 0.79 | LMNA (0.67) | ALDH1A1TP53KDM4EMAPTHRH3 | |
| SCHEMBL27658726 | 0.78 | SIGMAR1 (0.58) | L3MBTL1MEN1TSHRKMT2AALDH1A1 | |
| SCHEMBL3243725 | 0.77 | L3MBTL1 (0.89) | L3MBTL1MEN1TSHRKMT2AALDH1A1 | |
| SCHEMBL12660139 | 0.77 | KDM4E (0.64) | MEN1TSHRKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL14456892 | 0.76 | MEN1 (0.63) | L3MBTL1MEN1TSHRKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2336125-A1 | Thiazolopyridin-2-yloxy-phenyl and thiazolopyrazin-2-yloxy-phenyl amines as modulators of leukotriene A4 hydrolase | Janssen Pharmaceutica N.V. (BE) | 2011-06-22 | — | — | EP | disclosed |