Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 4/20 | 0.58 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 2/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.49 |
| ▸ | DRD3 | P35462 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 3/20 | 0.47 |
| ▸ | ESRRB | O95718 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24322242 | 0.90 | ESR1 (0.60) | ESR1NPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL23852035 | 0.90 | ESR1 (0.60) | ESR1NPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL23852037 | 0.90 | ESR1 (0.60) | ESR1NPC1HPGDRAB9ASMN1; SMN2 | |
| SCHEMBL24323673 | 0.87 | ESR1 (0.62) | ESR1NPC1RAB9ADRD2DRD3 | |
| SCHEMBL24323689 | 0.86 | SMN1; SMN2 (0.56) | NPC1HPGDRAB9ASMN1; SMN2ACHE | |
| SCHEMBL24322414 | 0.85 | CYP2D6 (0.59) | NPC1HPGDRAB9ASMN1; SMN2ACHE | |
| SCHEMBL24322422 | 0.83 | SMN1; SMN2 (0.53) | NPC1HPGDRAB9ASMN1; SMN2ACHE | |
| SCHEMBL24323052 | 0.79 | NPC1 (0.47) | NPC1HPGDRAB9ASMN1; SMN2ACHE | |
| SCHEMBL17164708 | 0.77 | ESR1 (0.89) | ESR1NPC1RAB9ADRD2DRD3 | |
| SCHEMBL17164697 | 0.77 | ESR1 (0.89) | ESR1NPC1RAB9ADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220089600-A1 | TGFß INHIBITOR AND PRODRUGS | FUNDACIÓ INSTITUT DE RECERCA BIOMÈDICA (IRB BARCELONA) (ES) | 2022-03-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220089600-A1 | TGFß INHIBITOR AND PRODRUGS | TGFB1, TGFBR1, TGFBR2 | ESR1 2521/4885NPC1 1441/4885HPGD 866/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.