Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | FAAH | O00519 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | DRD3 | P35462 | 1/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19577395 | 0.79 | ATF4 (0.62) | LMNASMN1; SMN2KMT2AALDH1A1DRD2 | |
| SCHEMBL5113209 | 0.74 | MTNR1A (0.73) | LMNASMN1; SMN2MAPTKMT2AL3MBTL1 | |
| SCHEMBL3446997 | 0.73 | SMN1; SMN2 (0.55) | LMNASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL31483051 | 0.71 | SMN1; SMN2 (0.53) | LMNASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL19577397 | 0.70 | ATF4 (0.62) | LMNAMAPTKMT2AL3MBTL1ALDH1A1 | |
| SCHEMBL9634003 | 0.70 | MTNR1A (0.53) | LMNASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL22395386 | 0.69 | ATF4 (0.61) | — | |
| SCHEMBL24324190 | 0.69 | ATF4 (0.52) | LMNASMN1; SMN2KMT2AALDH1A1NPC1 | |
| SCHEMBL9632340 | 0.69 | LTA4H (0.55) | LMNASMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL3585001 | 0.69 | CA12 (0.67) | LMNASMN1; SMN2MAPTL3MBTL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452453-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2022-04-13 | — | — | EP | disclosed |