Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | RAB9A | P51151 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 5/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | GAA | P10253 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24323271 | 0.83 | ALDH1A1 (0.56) | L3MBTL1LMNAMAPTGAASMN1; SMN2 | |
| SCHEMBL3842161 | 0.83 | HTT (0.61) | HTTRAB9AL3MBTL1LMNAMAPT | |
| SCHEMBL1027588 | 0.83 | HTT (0.66) | HTTRAB9AL3MBTL1LMNAMAPT | |
| SCHEMBL29783179 | 0.82 | RAB9A (0.73) | HTTRAB9AL3MBTL1LMNAMAPT | |
| SCHEMBL10163741 | 0.79 | HTT (0.70) | HTTRAB9AL3MBTL1LMNAMAPT | |
| SCHEMBL1286082 | 0.79 | GAA (0.62) | HTTRAB9ALMNAMAPTGAA | |
| SCHEMBL361384 | 0.77 | SMN1; SMN2 (0.63) | HTTRAB9AL3MBTL1LMNAMAPT | |
| SCHEMBL13130715 | 0.76 | HTT (0.66) | HTTRAB9AL3MBTL1LMNAMAPT | |
| SCHEMBL25433129 | 0.76 | MDM2 (0.52) | HTTRAB9AL3MBTL1LMNAGAA | |
| SCHEMBL805287 | 0.76 | RAB9A (0.61) | HTTRAB9AL3MBTL1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452453-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2022-04-13 | — | — | EP | disclosed |