Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | TXNRD1 | Q16881 | 2/20 | 0.52 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.49 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20380006 | 0.86 | L3MBTL1 (0.58) | ALDH1A1MEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL5698188 | 0.84 | TXNRD1 (0.54) | ALDH1A1MEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL5175379 | 0.84 | TXNRD1 (0.54) | ALDH1A1MEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL24324494 | 0.83 | HTT (0.58) | ALDH1A1MAPTL3MBTL1SMN1; SMN2LMNA | |
| SCHEMBL9403358 | 0.82 | GAA (0.58) | ALDH1A1MEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL24584925 | 0.82 | TXNRD1 (0.52) | ALDH1A1MEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL553682 | 0.82 | TXNRD1 (0.56) | ALDH1A1MEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL1269639 | 0.82 | CYP1A2 (0.56) | ALDH1A1MEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL24276173 | 0.81 | ALDH1A1 (0.59) | ALDH1A1MEN1KMT2AMAPTL3MBTL1 | |
| SCHEMBL183463 | 0.81 | ALDH1A1 (0.59) | ALDH1A1MEN1KMT2AMAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3452453-B1 | MODULATORS OF THE INTEGRATED STRESS PATHWAY | CALICO LIFE SCIENCES LLC (US) | 2022-04-13 | — | — | EP | disclosed |