Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24326409 | 0.79 | MAPT (0.43) | MAPTPKMGPR119ALDH1A1TDP1 | |
| SCHEMBL20994268 | 0.77 | ALDH1A1 (0.54) | PKMALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL29919658 | 0.74 | MAPT (0.52) | MAPTGPR119ALDH1A1HDAC1L3MBTL1 | |
| SCHEMBL3624023 | 0.74 | AR (0.52) | MAPTGPR119ALDH1A1HDAC1MAP4K4 | |
| SCHEMBL3435963 | 0.74 | GPR119 (0.45) | MAPTGPR119ALDH1A1L3MBTL1TDP1 | |
| SCHEMBL29919690 | 0.73 | ALDH1A1 (0.47) | MAPTGPR119ALDH1A1HDAC1SETD7 | |
| SCHEMBL15784121 | 0.73 | ALDH1A1 (0.44) | MAPTGPR119ALDH1A1SETD7TDP1 | |
| SCHEMBL17182248 | 0.72 | MGLL (0.45) | MAPTGPR119ALDH1A1TDP1LMNA | |
| SCHEMBL15777464 | 0.72 | MGLL (0.45) | MAPTGPR119ALDH1A1TDP1LMNA | |
| SCHEMBL19284226 | 0.71 | LMNA (0.46) | MAPTALDH1A1HDAC1SETD7LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3489231-B1 | PIPERAZINE DERIVATIVE | ASTELLAS PHARMA INC (JP) | 2021-06-09 | — | — | EP | disclosed |
| EP-3489231-A1 | PIPERAZINE DERIVATIVE | Astellas Pharma Inc. (JP) | 2019-05-29 | — | — | EP | disclosed |