Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.76 |
| ▸ | NPC1 | O15118 | 6/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.69 |
| ▸ | MAPT | P10636 | 3/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.69 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.62 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | MITF | O75030 | 1/20 | 0.55 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27324835 | 0.86 | KCNH2 (0.72) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL3427885 | 0.86 | RAB9A (1.00) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL26887340 | 0.81 | SPHK2 (0.58) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL15447851 | 0.79 | RAB9A (0.79) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL7070577 | 0.78 | SMN1; SMN2 (0.52) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL15447849 | 0.78 | RAB9A (0.81) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL16303842 | 0.76 | SMN1; SMN2 (0.42) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL17115025 | 0.76 | ADRB1 (0.47) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPT | |
| SCHEMBL8129981 | 0.76 | GRM2 (0.50) | RAB9ASMN1; SMN2NPC1ALDH1A1MAPT | |
| Hydrochloric Acid SCHEMBL15231570 | 0.74 | S1PR1 (0.45) | RAB9ASMN1; SMN2NPC1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022056042-A1 | INHIBITORS OF SPINSTER HOMOLOG 2 (SPNS2) FOR USE IN THERAPY | UNIVERSITY OF VIRGINIA PATENT FOUNDATION (US) | 2022-03-17 | — | — | WO | disclosed |