Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CXCR4 | P61073 | 8/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.47 |
| ▸ | CCR2 | P41597 | 1/20 | 0.47 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28957460 | 0.86 | SMN1; SMN2 (0.63) | SMN1; SMN2LMNAALDH1A1MAPTTSHR | |
| SCHEMBL5225958 | 0.86 | SMN1; SMN2 (0.59) | SMN1; SMN2LMNAALDH1A1MAPTTSHR | |
| SCHEMBL5225149 | 0.85 | SMN1; SMN2 (0.61) | SMN1; SMN2LMNAALDH1A1MAPTTSHR | |
| SCHEMBL5224880 | 0.84 | SMN1; SMN2 (0.62) | SMN1; SMN2LMNAALDH1A1MAPTTSHR | |
| SCHEMBL5223197 | 0.82 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNAALDH1A1MAPTTSHR | |
| SCHEMBL7986878 | 0.81 | MAOA (0.44) | SMN1; SMN2LMNAALDH1A1MAPTTSHR | |
| SCHEMBL7074835 | 0.80 | KMT2A (0.58) | SMN1; SMN2LMNAALDH1A1MAPTTSHR | |
| SCHEMBL7074013 | 0.80 | HDAC4 (0.56) | LMNAMAPTTSHRMAOAMAOB | |
| SCHEMBL7069987 | 0.79 | MAOA (0.52) | MAPTMAOAMAOBSIGMAR1 | |
| SCHEMBL7245509 | 0.79 | CXCR1 (0.58) | SMN1; SMN2ALDH1A1MAPTKCNH2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1025086-B1 | BENZAMIDINE DERIVATIVES AS FACTOR XA INHIBITORS | MERCK PATENT GMBH (DE) | 2003-06-25 | — | — | EP | disclosed |
| US-6492368-B1 | Benzamidine derivatives as factor XA inhibitors | MERCK PATENT GMBH (DE) | 2002-12-10 | — | — | US | disclosed |